Copper-based glass-ceramic as an efficient catalyst in the synthesis of pyrazolo[1,5-a] pyrimidineunder solvent-free condition with docking validation as Covid-19 main protease (Mpro) inhibitor
نویسندگان
چکیده
Copper-based oxide glass-ceramic was successfully synthesized through the single-step melt annealing technique. Synthesized glass-ceramics characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) supported with energy dispersive (EDX) mapping. Pyrazolo[1,5-a]pyrimidines 5a-f were via reaction of 5-amino-1H-pyrazole-4-carboxamide (1) enaminones 2a-f in presence catalyst powder under solvent-free condition. The molecular docking study demonstrated that COVID-19 main protease (MPro) inhibitor.
 
 KEY WORDS: Pyrazolopyrimidine, Enaminones, catalysis, Solvent-free, COVID-19
 Bull. Chem. Soc. Ethiop. 2021, 35(1), 185-196.
 DOI: https://dx.doi.org/10.4314/bcse.v35i1.16
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ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2021
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v35i1.16